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Administering low-dose intravenous ketamine transforms multimodal general anesthesia by targeting central pain pathways before surgical stimulation begins. Ketamine functions as a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, dampening dorsal horn wind-up and preventing acute central sensitization (Peltoniemi et al., 2016). When combined synergistically with gamma-aminobutyric acid (GABA) receptor agonists like propofol, it produces reliable hypnotic depth and somatic analgesia
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Why should you think twice before giving ONDANSETRON with TRAMADOL? 💊⚠️ This is an important drug interaction every medical student, doctor, nurse and healthcare professional should know. 🔴 TRAMADOL is a serotonergic opioid. It increases serotonin activity in addition to its opioid effects. 🟡 ONDANSETRON is a 5-HT3 receptor antagonist. Although the exact clinical significance of its serotonergic interaction remains debated, official prescribing information warns about serotonin syndrome when
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