CML is classified into 3 groups that help predict outlook. Doctors call these groups phases instead of stages. The phases are based mainly on the number of immature white blood cells (blasts) in the blood or bone marrow.

CML has three phases. The phase of your chronic myeloid leukemia (CML) plays a large part in determining the type of treatment you'll receive. Doctors use diagnostic tests to determine the phase of CML. Determining the CML phase is based primarily on the number of immature white blood cells (blasts) in the patient’s blood and bone marrow.

Jan 16, 2023 · Chronic myelogenous leukemia (CML), BCR-ABL1 -positive, is classified as a myeloproliferative neoplasm predominantly composed of proliferating granulocytes and determined to have the Philadelphia chromosome/translocation t (9;22) (q34;q11.2). CML affects both the peripheral blood and the bone marrow.

How do doctors work out your phase of CML? Different groups of CML experts have slightly different definitions of the 3 phases of CML. We have based our information below on the European LeukaemiaNet definition. This is the definition that researchers use in most of the recent CML clinical trials.

Oct 26, 2023 · Unlike most cancers, chronic myelogenous leukemia (CML) is classified into phases rather than stages, based partly on the percentage of immature white blood cells (blasts) in...

Treating chronic phase CML. The standard first treatment for chronic phase CML is a tyrosine kinase inhibitor (TKI), such as imatinib (Gleevec), nilotinib (Tasigna), dasatinib (Sprycel), bosutinib (Bosulif), or asciminib (Scemblix).

There are 3 phases of CML: Chronic phase. During this phase, you have fewer than 10% immature white blood cells, called blasts, in your blood or bone marrow. If there are symptoms, they're mild and get better with treatment. Most people diagnosed with CML are in this phase. It progresses more slowly. People can stay in this chronic phase for ...

Each phase of CML requires different treatment: For information about the drugs listed on this page, visit Drug Listings. Tyrosine kinase inhibitor (TKI) therapy is standard treatment for chronic phase CML. TKIs are often successful at managing CML for long periods of time. The following TKIs are approved as primary treatment for chronic phase CML:

Mar 20, 2025 · The WHO defines blast phase CML by 20% or more blasts in the bone marrow or peripheral blood. Extramedullary blast proliferation, such as myeloid sarcomas or infiltration into lymph nodes, skin, or the central nervous system, also qualifies a patient for this classification. A rising burden of chromosomal abnormalities, particularly complex ...

Oct 16, 2023 · The clinical manifestations of CML are insidious, changing somewhat as the disease progresses through its 3 phases (chronic, accelerated, and blast). Patients in the chronic phase may be...