We present evidence that Tall el-Hammam, a fortified Middle Bronze Age city in the Jordan Valley, was destroyed by an extraordinary high-energy event in approximately 1650 BCE. Excavations reveal that ...

Mitochondrial quality control (MQC) mechanisms – including biogenesis, dynamics, mitophagy, proteostasis, the unfolded protein response, and mitochondrial-derived vesicles – play critical roles in the ...

Background: Bladder cancer (BLCA) is one of the most common malignancies and the second most frequent urogenital tract tumor. Cell and gene therapy, which offer many advantages in treating BLCA, are ...

Pulmonary fibrosis (PF) is a progressive interstitial lung disease characterized by excessive extracellular matrix deposition and tissue scarring, and leading to impaired lung function and respiratory ...

Objective: The goal of this study was to examine the prognostic performance of optical flow ratio (OFR) among patients with coronary artery disease (CAD) after percutaneous coronary intervention (PCI) ...

Silver nanoclusters (AgNCs) have emerged as highly adaptable nanomaterials with vast potential in theranostic applications, by integrating therapeutic and diagnostic capabilities within a single ...

Kinases have a pivotal role in phosphorylation and kinase dysregulation has been implicated in the occurrence and progression of various diseases. By mid-2024 the Food and Drug Administration had ...

Mental health disorders (MHDs) have significant medical and financial impacts on patients and society. Despite the potential opportunities for artificial intelligence (AI) in the mental health field, ...

Herbal plants that contain aristolochic acids (AAs) have been widely used for medicinal purposes for centuries. However, human exposure to AAs via herbal or dietary intake is thought to be a causative ...

Within a socio-spatial theoretical approach, Knowledge Capitalism is a new capitalist phase of development emerging in the eighties of the 20th century, in which knowledge valorization becomes the ...

Background: Although 2-methylbutyrylcarnitine (2MBC) has been associated with metabolic disorders and promotes thrombosis, its effect on atherosclerosis remains elusive. This study was aimed at ...

Background: Fenofibrate (FF) is a BCS class II compound whose poor solubility poses challenges in drug delivery and bioavailability. Solid self-micro emulsifying drug delivery systems (S-SMEDDS) have ...