This important study investigated whether the nuclear receptor Nur77 is regulated by a non-canonical mechanism of ligand-induced disruption of its interaction with RXRg, similar to the family member ...

A research team led by Prof. Li Yunhai from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy ...

Using electron microscopy, researchers illustrate FusB's role in antibiotic resistance, providing a molecular-level ...

Huntington's disease is a genetic disorder that kills nerve cells in the brain, causing people to lose their cognitive and ...

Mice genetically engineered to lack the ability to make the amino acid cysteine, and fed a cysteine-free diet, lost 30% of ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Attempts to define dyskinesia at the biochemical or molecular level have proved difficult ... of these receptors might identify the mechanisms that result in dyskinesia induction.

Researchers have revealed the mechanism underlying GPCR function using a GPS nuclear magnetic resonance (NMR) technique.

Methylated DNA 6-TG is ultimately cytotoxic by a mechanism that depends on the cell's DNA mismatch repair system. One route of escape from the cytotoxicity of thiopurines is by inactivation of ...

The emergence and global spread of antimicrobial resistance (AMR) pose one of the most critical threats to public health in ...

Department of Pharmacognosy, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic ...