Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

A new study by Professor José Villalaín, Chair of Biochemistry and Molecular Biology at the Miguel Hernández University of ...

A new study by Professor José Villalaín, Chair of Biochemistry and Molecular Biology at the Miguel Hernández University of ...

A new study by Professor José Villalaín, Chair of Biochemistry and Molecular Biology at the Miguel Hernández University of ...

To answer these questions, we carried out multiscale simulations of C99 15–55 dimer in POPC bilayers and DPC micelles building on our previous successful predictions of the monomer structures. (12) We ...

Lipid nanoparticles have emerged as critical platforms for drug and gene delivery, with the success of mRNA COVID-19 vaccines highlighting their potential.

Scientists have identified a new type of protein in bacteria that could change our understanding of how these organisms interact with their environments.

The lipids self-assemble into an intricate and complex 3D cubic structure, with water channels and lipid bridges running throughout the entire particle that can be used to package small molecule ...

Review Article Published: July 2010 Structure-based discovery of antibacterial drugs Katie J. Simmons, Ian Chopra & Colin W. G. Fishwick Nature Reviews Microbiology 8, 501–510 (2010) Cite this ...

NMR spectroscopy is a critical tool for linking protein structure, dynamics and interactions to protein function, but is challenging to apply to high-molecular-weight proteins. The chemical ...

Vinyl monomers from soybean, sunflower, linseed, and olive oils were copolymerized with styrene (St), methyl methacrylate (MMA), and vinyl acetate (VAc) to determine the reactivity of biobased ...