Obicetrapib is a highly selective cholesteryl ester transfer protein inhibitor that reduces low-density lipoprotein (LDL) cholesterol levels. The efficacy and safety of obicetrapib have not been fu ...

Together, these data identify cholesterol in liver lipid droplets as a critical mediator of MASH and demonstrate that Coenzyme A synthase knockdown and bempedoic acid are therapeutic approaches to ...

A schematic illustration of the role of DHHC5 and CRYBG1 in controlling lacteal function and intestinal lipid absorption by maintaining the lipid raft association of VEGFR2.

Hepatic steatosis is one of the most obvious indicators of nonalcoholic fatty liver disease. However, the presence of many regions with a similar color and shape as lipid droplets in the ...

Researchers say they are exploring therapeutic options to block fatty acid accumulation and immunosuppressive signals between cancer cells and neutrophils.

Scientists have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge that has long been limited by the protective ...

By 6 months, lipid staining revealed that microglia in these mice had 30 percent smaller lipid droplet area than control microglia. The FIT2-deficient microglia were not entirely devoid of droplets, ...

Hence, lipid peroxidation, but not lipid production itself, causes photoreceptor neurotoxicity. The production and transfer of lipids from neurons to glia is a highly dose-sensitive process, as even ...

FABP4 plays a central role in driving the formation lipid-laden macrophages induced by unsaturated fats and enhances macrophage-tumor interactions, thereby promoting breast cancer migration and ...

Rab2A orchestrates Golgi-lipid droplet (LD) interactions Elucidating the precise subcellular positioning of Rab2A within hepatocytes is pivotal for unraveling its role in VLDL 2 lipidation.

The stressed neurons spurred surrounding glia to crank up production of lipid droplets. When they overexpressed tau in glia, but not in photoreceptor neurons, lipid droplet production fell by nearly ...