Certain biologic therapies, such as ustekinumab, significantly effect hematological and lipid parameters in patients with psoriasis.

Together, these data identify cholesterol in liver lipid droplets as a critical mediator of MASH and demonstrate that Coenzyme A synthase knockdown and bempedoic acid are therapeutic approaches to ...

Oregon Health & Science University, in collaboration with Oregon State University, has discovered the structural organization and protein components of a lipid-transfer complex known as LPD-3 ...

Hepatic steatosis is one of the most obvious indicators of nonalcoholic fatty liver disease. However, the presence of many regions with a similar color and shape as lipid droplets in the ...

Scientists have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge that has long been limited by the protective ...

Hence, lipid peroxidation, but not lipid production itself, causes photoreceptor neurotoxicity. The production and transfer of lipids from neurons to glia is a highly dose-sensitive process, as even ...

However, its impact on lipid droplet (LD) degradation in hepatocytes remains unclear. LDs, coated by perilipins (PLINs), are selectively exposed and degraded through chaperone-mediated autophagy (CMA) ...

The stressed neurons spurred surrounding glia to crank up production of lipid droplets. When they overexpressed tau in glia, but not in photoreceptor neurons, lipid droplet production fell by nearly ...

Color-tunable, lipid droplet-targeted carbonized polymer dots (CPDs) were fabricated by varying reaction precursors through one-pot solvothermal synthesis. They exhibit gradual luminescence ranging ...

As evolutionarily conserved organelles, lipid droplets perform many functions. Dysregulation of lipid droplet dynamics causes many metabolic diseases, such as obesity, diabetes, and fatty liver.