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Alveolar macrophage cell surface receptor TREM2 promotes lung fibrosis, study shows
Lung macrophages play a pivotal role in diseases like idiopathic pulmonary fibrosis. Two types of macrophages—the white blood ...
Protagonist Announces Nomination of PN-477, an Oral and Injectable GLP-1R, GIPR, and GCGR Triple Agonist Peptide Development Candidate for Obesity
A novel oral peptide PN-477o with once-daily dosing, high potency and activation of glucagon-like peptide-1 (GLP-1), ...
Medscape7d
Innate Immune Evasion Strategies of Influenza Viruses
Multiple studies have demonstrated that influenza viruses engineered to express NS1 proteins lacking specific functions (e.g., dsRNA binding, CPSF30 binding, PI3K binding or TRIM25 binding) are ...
A new Covid variant Nimbus aka ‘razor blade throat’ is on the rise. All you need to know
The variant - NB.1.8.1 is nicknamed Nimbus aka 'razor blade throat' Covid as it may cause painful sore throats and doctors in ...
C&EN21d
Mode of Binding of the Cyclic Agonist Peptide TC14012 to CXCR7: Identification of Receptor and Compound Determinants
We here report the the mode of binding of TC14012 to CXCR7 by combining the use of compound analogues, receptor mutants, and molecular modeling. We find that the mode of binding of TC14012 to CXCR7 is ...
PNAS26d
Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy | PNAS
Type 1 narcolepsy (T1N) is caused by hypocretin/orexin (HCRT) neuronal loss. Association with the HLA DQB1*06:02/DQA1*01:02 (98% vs. 25%) heterodimer (DQ0602), T cell receptors (TCR) and other immune ...
C&EN28d
Uncoupling the Structure–Activity Relationships of β2 Adrenergic Receptor Ligands from Membrane Binding
Ligand binding to membrane proteins may be significantly influenced by the interaction of ligands with the membrane. In particular, the microscopic ligand concentration within the membrane surface ...