Rearrangement of immunoglobulin heavy-chain variable (VH) gene segments has been suggested to be regulated by interleukin 7 signaling in pro–B cells.

The only immunoglobulin heavy-chain classes known so far in teleosts have been μ and δ. We identify here a previously unknown class, immunoglobulin ζ, expressed in zebrafish and other teleosts.

In addition, we found that the tRNA-Leu2 rearrangement occurred in the LTPF gene cluster in the mitochondrial genome of the F. multistriata, resulting in a new arrangement (T-PL-F). There was a tandem ...

In exon 16 of the MYH8 gene encoding perinatal myosin heavy chain, bidirectional sequencing demonstrated a transition from G to A at nucleotide 2094 (G2094A) (Figure 3A) that predicted an arginine ...

Clinical Manifestations of Dilated and Hypertrophic Cardiomyopathy Due to Missense Mutations in the Gene for Cardiac β-Myosin Heavy Chain.

The researchers found a way to look at the editing history of B cells in the human and mouse samples, by monitoring the frequency of a non-functional light chain genetic rearrangement in the B ...

TEL gene rearrangements due to the 12;21 chromosomal translocation are the most common molecular genetic abnormality in childhood acute lymphoblastic leukemia (ALL), occurring in approximately 25% of ...

Scientists have opened a new frontier in the fast-evolving field of gene editing with the discovery of a way to programme the recombination and rearrangement of DNA.

RenNano™ mouse has modified heavy chain constant regions to generate functional HCAbs. RenMice™ can generate robust immune response and produce fully human antibodies with great diversity ...