Multiplex qPCR is a popular area of interest for many assay developers. Thanks to distinct reporter dyes, multiple reactions can be combined into a single well, with each target detected independently ...

COVID-19 causes a severe cytokine storm leading to excessive inflammation of organs. Iguratimod—a safe drug already in use for treating rheumatoid arthritis—suppresses excessive inflammation ...

Using a preclinical mouse model, the team found that this drug duo activates the IL-6/JAK/STAT3 signaling pathway in liver macrophages, unleashing a cytokine storm-like inflammatory response.

Notably, nearly half of these failures stem from unexpected and unmanageable human toxicity, with cytokine release syndrome (CRS) being a primary challenge in the development of chimeric antigen ...

Cytokine release syndrome is caused by excessive cytokine release, and it affects immunotherapy patients and those with autoimmune diseases or severe infections.

Moreover, LDO promoted macrophage polarization from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 state and downregulated CCL2 expression, thereby mitigating the cytokine storm ...

Mo Jain, MD, PhD, Founder and Chief Scientific Officer of Sapient added: “We are excited to team up with Alamar to offer the best-in-class platform for high-sensitivity cytokine and chemokine ...

Sapient Partners with Alamar Biosciences to Extend Targeted Proteomics Services Using NULISA™ Assays for Cytokines, Chemokines, and Inflammatory Mediators ...

In an intensive genomic search for causes of cytokine storm, the research team used autopsy samples obtained from 40 patients who died from COVID-19.