Shop 2016 Lexus IS 350 vehicles in Rochester, NY for sale at Cars.com. Research, compare, and save listings, or contact sellers directly from 25 2016 IS 350 models in Rochester, NY.

Shop 2022 Lexus IS 350 vehicles in Lithia Springs, GA for sale at Cars.com. Research, compare, and save listings, or contact sellers directly from 5 2022 IS 350 models in Lithia Springs, GA.

Old school muscle with new luxury, hard to beat that combination for your Car Pro.  I've got a beauty this week, and it is ...

The five-door model lasted just a single generation before being discontinued, yet it still holds a place in the hearts of ...

We still do not officially know if this car is either a Toyota or a Lexus, but we do know that it will hit the road and GT3 ...

Lexus' rear-wheel drive sports sedan. The IS350 F Sport is the more powerful of the IS models, not counting the hi-end IS-F with a 3.5-litre six cylinder engine.

The Lexus GS, IS, LS, GX, and LX offer V8 engines in a variety of automotive segments to fit what you're looking for.