This review provides an overview of the clinical, genetic, molecular, and cellular aspects of the Brugada syndrome, incorporating the results of 2 recent consensus conferences.

Like the long-QT and short-QT syndromes, Brugada syndrome is traditionally thought of as a primary electrical cardiac disease arising in myocardium that is otherwise structurally normal.

Conclusions— In Brugada syndrome, AES is commonly located in the right ventricle epicardium and ajmaline exposes its extent and distribution, which is correlated with the degree of coved ST-elevation.

Brugada syndrome This PrimeView highlights the mechanisms of Brugada syndrome and summarises its epidemiology, diagnosis and management.