A critical component of antibody generation is the T-dependent (TD) activation of naive B-cells in secondary lymphoid organs, which depends on two distinct signals: B-cell receptor (BCR) engagement by ...

Chimeric antigen receptor (CAR) T cells targeting CD19 have transformed the treatment of B-cell cancers, but many patients do not have long-term remission. We designed an anti-CD19 enhanced (armore ...

Then, in 2021, the lab showed that clonal burst happen by what they dubbed “inertial” cell cycling, in which B cells multiply continuously without selection between each round.

Mechanisms of resistance to TIL-ACT are ill-defined. The authors report that transfer of TILs caused immune selection of a resistant melanoma cell clone in one patient. T-cell collection from multiple ...

However, it is unclear whether vascular endothelial cells (ECs) are also replenished by stem/progenitor cells with EC-repopulating potential residing in blood vessels. It has been reported recently ...

Recent larger-scale studies of patients with cancer and longitudinal population cohorts have revealed how age-related expansions of mutant hematopoietic cells (clonal hematopoiesis [CH]) have ...

While we find that the extent of selection stringency dictates clonal dominance, limited antigen availability on follicular dendritic cells is shown to expedite the loss of diversity of B cells as ...

Context Key Objective Considering the prominent role of inflammatory elements in the lung microenvironment and emerging evidence positing the lung as a niche of hematopoietic progenitor cells, clonal ...

The blood stem cell mutation, known as DNMT3A R882, leads to the growth of a large population, or "clonal outgrowth," of circulating blood cells that also contain this mutation. In general, such ...

High degree of clonal persistence and excess of inter-individual convergence are observed in human memory B cell repertoires, along with signatures of both negative and positive selection in most ...

The advantageous mutations that drive clonal hematopoiesis are under positive selection, just like mutations in cancer genes which are responsible for the malignization of cells.