More information: Silvia Vaena et al, Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response, Cell Reports (2021). DOI: 10.1016/j.celrep.2021. ...

The application of CAR-T cell therapy against solid tumors is often hindered by the dense and rigid tumor extracellular ...

A team of researchers from the Changchun Institute of Applied Chemistry has developed a nanogel-based strategy to enhance the ...

By sparking the immune system into action, radiation therapy makes certain tumors that resist immunotherapy susceptible to ...

One therapy being pursued to establish effective antitumor immunity is adoptive T-cell ... et al. CRISPR activation and interference screens decode stimulation responses in primary human T cells.

The less robust antitumor effects of CAR T-cell therapies when evaluated in patients with solid tumor malignancies have been attributed to the complex tumor microenvironment, antigen heterogeneity, ...

Prof. LIANG Xingjie's team from the National Center for Nanoscience and Technology, along with Prof. GONG Ningqiang from the University of Science and Technology of China, has developed a biomimetic ...

An experimental mRNA vaccine that supercharges existing cancer treatments could be laying the groundwork for a “universal” cancer vaccine, according to the team behind the breakthrough. Scientists at ...

The importance of neoantigens as critical targets for effective antitumor T-cell responses is underlined by (1) the association of tumor mutational burden and efficacy of immune checkpoint inhibition ...

The current study, presented Monday, confirmed partial response in a heavily pretreated patient who did not respond to prior PD-1 therapy. Results showed more than 50% depletion of CCR8+ Tregs and ...