More information: Silvia Vaena et al, Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response, Cell Reports (2021). DOI: 10.1016/j.celrep.2021. ...

A study led by Prof. Liang Xingjie's team from the National Center for Nanoscience and Technology of the Chinese Academy of ...

One therapy being pursued to establish effective antitumor immunity is adoptive T-cell ... et al. CRISPR activation and interference screens decode stimulation responses in primary human T cells.

Prof. LIANG Xingjie's team from the National Center for Nanoscience and Technology, along with Prof. GONG Ningqiang from the University of Science and Technology of China, has developed a biomimetic ...

Most patients who have a relapse after anti-CD19 CAR T-cell therapy or have resistance to such therapy continue to have CD19 expression on malignant B cells. 11 Although CD19 antigen loss can ...

The less robust antitumor effects of CAR T-cell therapies when evaluated in patients with solid tumor malignancies have been attributed to the complex tumor microenvironment, antigen heterogeneity, ...

The importance of neoantigens as critical targets for effective antitumor T-cell responses is underlined by (1) the association of tumor mutational burden and efficacy of immune checkpoint inhibition ...

Immune checkpoint inhibitors (ICIs) are a type of immunotherapy or cancer treatment that targets specific immune cells known ...

The current study, presented Monday, confirmed partial response in a heavily pretreated patient who did not respond to prior PD-1 therapy. Results showed more than 50% depletion of CCR8+ Tregs and ...