The two conformational changes follow only upon ATP binding to the opposite head; this ensures tight 1:1 coupling, because the energy from one ATP hydrolysis is apparently used to prevent the next ...

In ATP hydrolysis, water is used to split apart adenosine triphosphate (ATP) to create adenosine diphosphate (ADP) to get energy. ATP hydrolysis energy (AHE) is then used in the activities of ...