Next, we asked whether peptides, which represent the last β-hairpin (hp18) of either hVDAC1 or yeast Porin, are able to mediate also in vivo mitochondrial targeting of a passenger domain. To that ...

He found that the antibody hugged the 10 N-terminal amino acids of the truncated Aβ, which had folded into a unique β-hairpin. Inspired by this conformation, the researchers synthesized TAPAS, a ...

Aβ1-40 within this cavity adopted a β-hairpin with two strands, 17-23 and 30-36, connected by intramolecular backbone hydrogen bonds. Importantly, the cavity of ZAβ3 dimer was inaccessible to water, ...

Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By linking a disease-related protein to one that triggers a cell's demolition ...

"Who will watch the watchers?" asked Roman poet Juvenal way back in the first century C.E. Nature has been addressing that ...

They saw the amyloid beta protein was folded back on itself, in a hairpin-shaped structure. “… we report that TAP01 family antibodies uniquely bind to a novel, pseudo β-hairpin conformation ...

image: De novo design of a nanopore for single-molecule detection that incorporates a β-hairpin peptide view more . Credit: Ryuji Kawano, Tokyo University of Agriculture and Technology ...