Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By linking a disease-related protein to one that triggers a cell's demolition ...

The authors use three methods, including matrix scoring algorithm, increment of diversity algorithm and Random Forest algorithm. They are used to predict β-hairpin motifs in the ArchDB-EC and ArchDB40 ...

"Who will watch the watchers?" asked Roman poet Juvenal way back in the first century C.E. Nature has been addressing that ...

SVS-1 is designed to remain unfolded and inactive in aqueous solution but to preferentially fold at the surface of cancer cells, adopting an amphiphilic β-hairpin structure capable of membrane ...

As connectors of adjacent β-strand secondary structure, turn regions also influence the entropic penalty for the assembly of local β-hairpin structure, and this plays an important role in the ...

The spatial constraints imposed by the tunnel walls disfavor β‐structure formation; density that can accommodate a structured β‐hairpin is observed only upon reaching the vestibule, as more space for ...

As the growing peptide reaches the end of the tunnel, the N‐terminal part of the nascent chain refolds to a β‐hairpin structure that remains dynamic until its release from the ribosome. Contacts with ...

HSA shifts the conformational ensemble towards more disordered states and alters the β-sheet association patterns. In particular, the frequent association of Q15-V24 and N27-V36 regions into β-hairpin ...

Mitochondrial β-barrel proteins are synthesized in the cytosol before being targeted to the organelle. Here, Jores et al.show that a specialized hydrophobic β-hairpin motif is the previously ...