Panel A shows abnormal expression of major-histocompatibility-complex (MHC) class I antigen on the sarcolemma and sarcoplasm of muscle fibers, with a predilection for perifascicular muscle fibers.

This hinders the muscle fiber's ability to heal, ... interest to patients with Niemann-Pick disease type A since the pre-clinical model for this disease also manifests poor sarcolemma repair." ...

It is caused by microruptures in the cell membrane of our muscle fibers. ... Dysferlin-mediated phosphatidylserine sorting engages macrophages in sarcolemma repair. Nature Communications, 2016 ...