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A complex regulatory network is known to promote functional exhaustion of CD8 + T-cells, but less is known about those factors that protect CD8 + T-cells from exhaustion. This study identifies the ...

Three-time Olympic champion Irina Rodnina, now a politician in the Russian State Duma, responded to the US announcement by claiming that the US officials will not be missed. "I do not know how this ...

Based on several lines of interesting data, the authors conclude that FMRP, though associated with stalled ribosomes, does not determine the position on the mRNAs at which ribosomes stall. Although ...

Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are a growing class of natural products. Multinuclear nonheme iron-dependent oxidative enzymes (MNIOs, previously DUF692) are ...

The ribosomal peptidyl transferase is a biologically essential catalyst responsible for protein synthesis. The reaction is expected to proceed through a transition state approaching tetrahedral ...