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Falcipains (FPs) are hemoglobinases of Plasmodium falciparum that are validated targets for the development of antimalarial chemotherapy. A combined ligand- and structure-based virtual screening of ...

Inhibition of the S-adenosyl methionine (SAM)-producing metabolic enzyme, methionine adenosyltransferase 2A (MAT2A), has received significant interest in the field of medicinal chemistry due to its ...

Many drug targets are localized to particular subcellular compartments, yet current drug design strategies are focused on bioavailability and tissue targeting and rarely address drug delivery to ...

Weight-loss drugs like Ozempic and Wegovy are used by more than 15 million adults in the U.S., or 4.5% of the population. Despite their effectiveness, they have drawbacks. Their effect may not ...

Massive shipments of previously unknown recreational designer drugs and potent new opioids are threatening Europe, while traffic of cocaine and cannabis is worsening, according to the European ...

CARLSBAD, Calif., June 04, 2025 (GLOBE NEWSWIRE) -- Design Therapeutics, Inc. (Nasdaq: DSGN), a clinical-stage biotechnology company developing treatments for serious degenerative genetic diseases ...

A team of chemists at the University of Cambridge has developed a powerful new method for adding single carbon atoms to molecules more easily, offering a simple one-step approach that could ...

Considering the high cost associated with determining reaction affinities through in vitro experiments, virtual screening of potential drugs bound to specific protein pockets from vast compounds is ...

NuScale’s application for standard design approval was accepted for NRC review in July 2023. The standard design approval is based upon the staff’s final safety evaluation report, issued on 28 May.

After Clint Eastwood called a new interview with him "phony," the journalist behind the piece says it's aggregated from quotes he gave to the HFPA over many years.

Designer Sebastiaan de With imagines what Apple's upcoming OS redesign might look like ahead of WWDC 2025. With WWDC less than a week away and Apple dropping hints that changes are coming ...