Complete neutralization of neurotoxins was observed in patch-clamp experiments in a rhabdomyosarcoma cell line expressing the nicotinic acetylcholine receptor.

Structure Therapeutics is developing a series of both DACRAs and SARAs, as both approaches have demonstrated potential as obesity and chronic weight management treatment. Structure’s lead amylin-based ...

The nicotinic acetylcholine receptor at the nerve-muscle synapse resides in an asymmetric cholesterol-rich membrane, the inner leaflet of which consists largely of ordered lipid assemblies due to a ...

Keywords: nicotinic acetylcholine receptors, α-conotoxins, RgIA, structure, molecular modeling, molecular dynamics Citation: Zouridakis M, Papakyriakou A, Ivanov IA, Kasheverov IE, Tsetlin V, Tzartos ...

To determine the correlation between SARS-CoV-2 and nicotinic acetylcholine receptors (nAChRs), the researchers studied a panel of co-crystal structures along with the neurotoxin binding motif ...

Summary The nicotinic acetylcholine receptor, a pentameric ligand-gated ion channel, converts the free energy of binding of the neurotransmitter acetylcholine into opening of its central pore. Here we ...

α-Conotoxin Vc1.1 inhibits the nicotinic acetylcholine receptor (nAChR) α9α10 subtype and has the potential to treat neuropathic chronic pain. To date, the crystal structure of Vc1.1-bound α9α10 nAChR ...

Three-dimensional structures of nicotinic acetylcholine receptor determined by cryo-EM, courtesy of Hibbs Lab. "When this receptor binds to either the neurotransmitter acetylcholine or to nicotine ...

Three-dimensional structures of nicotinic acetylcholine receptor determined by cryo-EM, courtesy of Hibbs Lab. "When this receptor binds to either the neurotransmitter acetylcholine or to nicotine ...

The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits are likely to be the evolutionary precursors to the entire cys-loop superfamily of ligand-gated ion channels, which includes ...