Amino acids play a fundamental role in regulating how cells respond to drugs. These molecules, which form proteins, act like ...

Lipid-mediated protein-protein interactions between an amphitropic protein, dimeric tubulin, and an integral membrane protein, gramicidin A. Both global and local membrane properties play a role and ...

Abstract Integral membrane proteins carry out essential functions in the cell, and their activities are often modulated by specific protein-lipid interactions in the membrane. Here, we elucidate the ...

The alkaline pH decreases non-covalent protein‐protein interactions and releases peripheral membrane proteins to the supernatant (Kim et al, 2015). As expected, the Mcr1 OM isoform remained in the ...

Figure 1: The Membrane Mimetic-Thermal Proteome Profiling (MM-TPP) experimental workflow. 1) Crude membranes are prepared from the liver organ. 2) Integral membrane proteins (IMPs) are solubilized ...

Next, we apply our model to a couple of other peripheral proteins, namely, Snf7, a core component of the ESCRT-III complex, and the PH domain of evectin-2. We find that our model captures the ...

Moreover, we provide an overview on the role of membrane scaffold proteins, particularly tetraspanins, flotillins/reggies, and caveolins in controlling leukocyte migration both in vitro and in vivo.

A survey of 1,590 putative integral, peripheral and lipid-anchored membrane proteins from Saccharomyces cerevisiae reveals unexpected physical associations underlying the membrane biology of ...

The alignment of membrane proteins provides pertinent structural and dynamic information. Structural topology data gleaned from such studies can be used to determine the functional mechanisms ...

Many of the integral membrane proteins interact with a stable network of structural proteins and cannot be extracted by detergents (7), a problem that is relevant for the analysis of any other complex ...