The UAB researchers showed that TREM2 — which stands for triggering receptors expressed on myeloid cells 2 — is predominantly ...

A novel oral peptide PN-477o with once-daily dosing, high potency and activation of glucagon-like peptide-1 (GLP-1), ...

The variant - NB.1.8.1 is nicknamed Nimbus aka 'razor blade throat' Covid as it may cause painful sore throats and doctors in ...

With the help of their new development, they have also analyzed how novel influenza viruses use alternative receptors to enter target cells. The results were recently published in two papers in ...

Using the example of a seasonal influenza A virus, the researchers used high-resolution and super-resolution microscopy to show that contact between the virus and the cell surface triggers a cascade ...

Glycan binding properties of respiratory viruses have been difficult to probe due to a lack of biologically relevant glycans for binding studies. Here, a stop-and-go chemoenzymatic methodology is ...

More specifically, “a Gln 226 Leu substitution switched Texas HA binding specificity to human-type receptors, which was enhanced when combined with an Asn 224 Lys mutation.

A Gln226Leu mutation in the receptor-binding site (RBS) of Texas H5 HA caused a complete switch in specificity from α2-3 to α2-6 sialosides, reflecting a shift to human receptor preference.

The mutated hemagglutinin’s binding affinity to human-type receptors was weak, but Paulson noted that this was also the case when the H1N1 virus that caused the 2009 swine flu pandemic first ...

Better receptor binding doesn’t necessarily cause disease on its own. Several other factors are important, such as the virus’s ability to replicate and proliferate in the body.