News

Protagonist Announces Nomination of PN-477, an Oral and Injectable GLP-1R, GIPR, and GCGR Triple Agonist Peptide Development Candidate for Obesity
A novel oral peptide PN-477o with once-daily dosing, high potency and activation of glucagon-like peptide-1 (GLP-1), ...
A new Covid variant Nimbus aka ‘razor blade throat’ is on the rise. All you need to know
The variant - NB.1.8.1 is nicknamed Nimbus aka 'razor blade throat' Covid as it may cause painful sore throats and doctors in ...
ahajournals.org17d
Role of Antibodies and Their Specificities in Atherosclerotic Cardiovascular Disease | Arteriosclerosis, Thrombosis, and Vascular Biology - AHA/ASA Journals
Moreover, the considerable differences between mouse and human immunoglobulin and Fc receptor subclasses and their expression patterns, as well as the binding of ligands other than immunoglobulins (eg ...
C&EN20d
Mode of Binding of the Cyclic Agonist Peptide TC14012 to CXCR7: Identification of Receptor and Compound Determinants
We here report the the mode of binding of TC14012 to CXCR7 by combining the use of compound analogues, receptor mutants, and molecular modeling. We find that the mode of binding of TC14012 to CXCR7 is ...
PNAS26d
Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy | PNAS
Type 1 narcolepsy (T1N) is caused by hypocretin/orexin (HCRT) neuronal loss. Association with the HLA DQB1*06:02/DQA1*01:02 (98% vs. 25%) heterodimer (DQ0602), T cell receptors (TCR) and other immune ...
C&EN28d
All-Atom Simulations Reveal the Intricacies of Signal Transduction upon Binding of the HLA-E Ligand to the Transmembrane Inhibitory CD94/NKG2A Receptor
A variety of nonameric peptides allow receptor binding to HLA-E, but only a handful of them permit effective recognition, indicating that even a small change in their amino acid sequence can lead to a ...