Despite advances, the roles of genetics and microenvironment in CLL are not fully understood, and curative treatments may hinge on a dual approach targeting both.

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Results: We present an allelic atlas of immunoglobulin heavy chain (IgH) variable regions, illustrating the diversity of allelic variants across 33 IGHV family germline sequences by sequencing the IgH ...

The mechanism of IgM assembly remained incompletely understood. This work demonstrates how J-chain outcompetes the sixth dimeric IgM subunit during assembly of pentamers, and how secretion of aberrant ...

Image Credit: ktsdesign/Shutterstock Background The human immunoglobulin (Ig) heavy chain (HC) locus has remarkable polymorphisms with a high degree of structural and allelic variation.

Reference Ursule-Dufait C, Bengoufa D, Theodorou I, Villesuzanne C, Arnulf B. Heavy chain/light chain assay is a useful biomarker for diagnosis and management of patients with cold agglutinin disease.

The light chains that make up the antibody have a variable and a constant region, whereas the heavy chains consist of three variable and one constant region.

New criteria for response to treatment in immunoglobulin light chain amyloidosis based on free light chain measurement and cardiac biomarkers: impact on survival outcomes.

We also used a published human naïve dataset to investigate the CDR-H3 properties of heavy chains paired with kappa and lambda light chains and probed the Protein Data Bank to investigate the ...

The B-1a cell heavy chain antibody repertoire differs dramatically from the follicular and marginal zone B cell repertoire and is defined by distinct mechanisms driven by self antigens rather than ...