CD19-CAR T-cell treatment is a novel option of deep B cell depletion with promising results across different rheumatologic and musculoskeletal diseases (RMD).

A critical component of antibody generation is the T-dependent (TD) activation of naive B-cells in secondary lymphoid organs, which depends on two distinct signals: B-cell receptor (BCR) engagement by ...

Clonal selection A process in which B cells coding for antibodies with varying antigen affinities compete to interact with antigen‐presenting immune cells such as follicular T helper cells and ...

Boehringer Ingelheim has joined the surge of companies entering the B-cell depletion space. But while its peers have largely focused on CAR-Ts and bispecifics, the German drugmaker has paid Cue ...

Then, in 2021, the lab showed that clonal burst happen by what they dubbed “inertial” cell cycling, in which B cells multiply continuously without selection between each round.

These alterations are reflective of underlying tumor cell clonal evolution with selection for clones harboring resistance mechanisms in the presence of initially effective treatment.

Mechanisms of resistance to TIL-ACT are ill-defined. The authors report that transfer of TILs caused immune selection of a resistant melanoma cell clone in one patient. T-cell collection from multiple ...

However, it is unclear whether vascular endothelial cells (ECs) are also replenished by stem/progenitor cells with EC-repopulating potential residing in blood vessels. It has been reported recently ...

The diffuse large B-cell lymphoma treatment landscape is evolving with Pola-R-CHP and CAR T-cell therapy moving into the frontline setting.

Recent larger-scale studies of patients with cancer and longitudinal population cohorts have revealed how age-related expansions of mutant hematopoietic cells (clonal hematopoiesis [CH]) have ...

High degree of clonal persistence and excess of inter-individual convergence are observed in human memory B cell repertoires, along with signatures of both negative and positive selection in most ...

The advantageous mutations that drive clonal hematopoiesis are under positive selection, just like mutations in cancer genes which are responsible for the malignization of cells.