Clonal selection articles from across Nature Portfolio Atom RSS Feed Clonal selection is a process proposed to explain how a single B or T cell that recognizes an antigen that enters the body is ...

Then, in 2021, the lab showed that clonal burst happen by what they dubbed “inertial” cell cycling, in which B cells multiply continuously without selection between each round.

They investigated how B cells balance mutation and selection to generate highly effective antibodies while avoiding harmful errors.

When B cells are in response-to-invader mode, they undergo what is termed a "clonal expansion," which can occur in a variety of tissues.

These findings in axillary and inguinal lymph nodes were compatible with diagnoses of T-cell–rich B-cell lymphoma and nodular lymphocyte-predominant Hodgkin's disease, respectively.

All cells within the same cancer are not the same. They all have genetic errors that turn them into tumour cells, but these errors are not identical. In each cancer, there are populations of cells ...

A study published in Cell Stem Cell reveals that some mutations in blood stem cells might help protect against late-onset Alzheimer's disease.

Researchers in the School of Biomedical Engineering, Science and Health Systems have helped to create the first “anatomic atlas” of B-cell clone lineages, their properties and tissue connections.

The advantageous mutations that drive clonal hematopoiesis are under positive selection, just like mutations in cancer genes which are responsible for the malignization of cells.

Recent larger-scale studies of patients with cancer and longitudinal population cohorts have revealed how age-related expansions of mutant hematopoietic cells (clonal hematopoiesis [CH]) have ...

Immunome, Inc., a biopharmaceutical company that utilizes its human memory B cell platform to discover and develop first-in-class antibody therapeutics, today announced the publication of a peer ...