Scientists have found four new anti-CRISPR proteins that are distributed across different environments. The new study suggests that some anti-CRISPR proteins are more widespread in nature than ...

Anti-CRISPR proteins could help put the brakes on gene editing Scientists are exploring the proteins’ potential as a way to control CRISPR and reduce off-target effects by Charles Q. Choi ...

CRISPR–Cas adaptive immune systems are widespread in prokaryotes. In this Progress article, Maxwell and colleagues highlight how phages and other mobile genetic elements inactivate CRISPR–Cas ...

We are investigating so-called anti-CRISPRs: proteins or other molecules that phages use to inhibit CRISPR. A bacterium that has CRISPR might be able to stop a phage from infecting. But if the phage ...

Using a method they developed to screen DNA from human microbiomes, Fred Hutch scientists discovered a new kind of anti-CRISPR that viruses use to block the DNA-chopping action of CRISPR, which ...

While most known anti-CRISPR proteins block steps along this path such as crRNA binding or target recognition, AcrVIB1 adopts a radically different strategy: Rather than blocking the binding of ...

UCSF researchers have discovered a way to switch off the widely used CRISPR-Cas9 gene-editing system using newly identified anti-CRISPR proteins that are produced by bacterial viruses.

Today’s research shows how one of these viral anti-CRISPR proteins works, and how it affects a commonly used type of gene-editing tool. The researchers found that the protein AcrIIA4 mimics DNA ...

Viruses developed a weapon to thwart the Cas9 protein, which is the scissors that bacteria use to obliterate viruses. A new UC Berkeley and UCSF study shows that these anti-CRISPR proteins can ...

CRISPR holds a lot of promise but there’s definitely room for improvement. Researchers have identified anti-CRISPR proteins that can act as an off switch for the gene editing system, making it ...

Current anti-CRISPR proteins are not abundant in nature. and have been identified by studying the DNA of the phages that were able to infect bacteria harbouring CRISPR-Cas9.