Organ-on-a-chip systems offer a more accurate, ethical, and scalable alternative to animal testing in drug discovery and ...

Sexual behavior and sex preference in animals and humans are shaped by complex interactions between the brain and hormones during early development. One critical factor is exposure to androgens (male ...

Alopecia areata, which can lead to permanent hair loss in some cases, can cause significant emotional challenges. Many people with alopecia areata face ongoing stress, anxiety, and other mental ...

Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of ...

Besides these drug-induced animal models, intratracheal delivery of an adenoviral gene vector encoding biologically active TGF-β1 has been shown to produce prolonged severe fibrosis in rat lung ...

-There are multiple treatment options for alopecia areata as systemic therapies such as immunosuppressants and local treatments such as hair growth stimulants, but it is unclear how helpful they are ...

This article highlights our work toward the identification of a potent, selective, and efficacious acidic mammalian chitinase (AMCase) inhibitor. Rational design, guided by X-ray analysis of several ...

XPro™ Treatment Post-TBI Prevents Short- and Long-Term Alzheimer’s-like Pathology in transgenic mice ...

Alopecia areata (AA) is an autoimmune disorder causing non-scarring hair loss, ranging from mild to severe forms. Most research has focused on immune dysregulation in the skin, with limited ...

After the DNA sequence of the boy’s genome showed a mutation in the VMA21 gene, one of the known causes of XMEA, University of Alabama at Birmingham and Children’s of Alabama pediatric neurologist ...

This study aimed to evaluate the long-term efficacy and safety of azathioprine as a systemic monotherapy for moderate to severe alopecia areata. A total of 63 patients (27 females [42.9%] and 36 males ...

As summarized in Figure 3, studies investigating cardiac metabolism in these models revealed increased uptake and oxidation of long-chain FAs, decreased glucose utilization, and diminished metabolic ...