Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By linking a disease-related protein to one that triggers a cell's demolition ...

The rapidly increasing demand on power density levels of electric vehicle (EV) drive systems is pushing the boundaries of traction motor performance. Hairpin windings are becoming a popular option for ...

The 17 amino acid cationic β-hairpin AMP tachyplesin (2.27 kDa) (Nakamura et al., 1988) is a promising candidate AMP because it displays broad-spectrum, potent antibacterial and antifungal efficacy, ...

Hairpin winding has been widely applied in passenger electrical vehicle (EV) industry, as a key technology brick that enables step-change improvements on power density and efficiency of traction ...

Our group recently reported covalent macrocyclic β-hairpin inhibitors for the same target. (209) We designed the β-hairpin to mimic one strand of Tcf4 bound to β-catenin (Figure 24 B); the Tcf4 strand ...

Leucine/Isoleucine Substitution Scanning of Tryptophan Residues to Reduce the Toxicity of β‑Hairpin Peptide N2W2 0 views 0 shares 0 downloads ...

The latter switches from a helical hairpin packed against the NTD to a five-stranded β-roll upon displacement by RNA polymerase binding. Here, we use exchange-based NMR to probe fold-switching ...