Recent structural studies of β-III-spectrin and related cytoskeletal proteins revealed N-terminal sequences that directly bind actin. These sequences are variable in structure, and immediately precede ...

Spectrin proteins form a flexible, elastic scaffold beneath the plasma membrane, conferring mechanical stability and organising membrane domains. Comprised of α and β subunits assembled into ...

Just as you could not stand tall or move without your bony frame, each neuron has its own skeletal scaffold of interconnected tubes of protein that gives it shape, traffics cargo, and allows it to ...

Spectrin and ankyrin are two essential proteins acting like bricks and mortar to shape and fortify cell membranes. But distinguishing which protein is the brick and which is the mortar has turned out ...

Rochester, Minn. -- Mayo Clinic researchers have discovered that genetic variants in a neuro-associated gene called SPTBN1 are responsible for causing a neurodevelopmental disorder. The study, ...

Mayo Clinic researchers have discovered that genetic variants in a neuro-associated gene called SPTBN1 are responsible for causing a neurodevelopmental disorder. The study, published in Nature ...

A team of researchers has developed a new method to screen FDA-approved drugs to determine if they could be repurposed or improved to help patients with a rare, debilitating disease of the nervous ...

Researchers have discovered that genetic variants in a neuro-associated gene called SPTBN1 are responsible for causing a neurodevelopmental disorder. The study is a first step in finding a potential ...