Nature

DNA polymorphism and epigenetic marks modulate the affinity of a scaffold/matrix attachment region to the nuclear matrix

Mechanisms that regulate attachment of the scaffold/matrix attachment regions (S/MARs) to the nuclear matrix remain largely unknown. We have studied the effect of simple sequence length polymorphism ...
Indiatimes

Scientists from Pune university prepare genome map of Scaffold/Matrix Attachment Regions

A team of scientists from Savitribai Phule Pune University (SPPU) and other institutes have, for the first time been able to prepare a map of human ‘Scaffold/Matrix Attachment Regions (S/MARs)’ which ...
Nature

Progress and Prospects: The design and production of plasmid vectors

Large scale manufacture of pure, stable plasmid is required for gene transfer studies. Minicircles in which the backbone has been removed may offer advantages over conventional plasmids. Sequences in ...
EurekAlert!

New gene delivery approach could allow long-term persistence in proliferating cells

New Rochelle, NY, Sept. 22, 2017 -- Researchers added a scaffold/matrix attachment region (S/MAR) to a conventional adeno-associated virus (AAV) vector used for gene transfer, and the modified vectors ...
News Medical

Novel approach facilitates long-term persistence of AAV vector genomes in proliferating cells

Researchers added a scaffold/matrix attachment region (S/MAR) to a conventional adeno-associated virus (AAV) vector used for gene transfer, and the modified vectors were able to establish colonies and ...