A strategy for isolation of RNP complexes. Our strategy comprises seven steps that we optimized for efficient isolation of intact RNP complexes (Fig. 1 and Supplementary Methods online).Collected ...

CRISPR-Cas systems are widely used in genome engineering applications. They contain RNA-guided ribonucleoprotein (RNP) complexes that selectively modify DNA sequences at any specific location in the ...

The company developed this platform process for manufacturing RNP complexes using its off-the-shelf GMP-grade CRISPR proteins. Aldevron introduced catalog GMP CRISPR proteins in 2017, an industry ...

Advances in gene-editing technology enable efficient, targeted ex vivo engineering of different cell types, which offer a potential therapeutic platform for most challenging disease areas. CRISPR ...

Recent studies have revealed remarkable complexity in the biogenesis, trafficking and mechanisms of action of small nuclear and small nucleolar ribonucleoproteins (RNPs). The principles of RNP ...

We now know that RNA has been leading a secret life, regulating gene expression and partnering with proteins to form catalytic ribonucleoprotein (RNP) complexes. One of those RNPs is telomerase ...

We now know that RNA has been leading a secret life, regulating gene expression and partnering with proteins to form catalytic ribonucleoprotein (RNP) complexes. One of those RNPs is telomerase ...

This study, spearheaded by two brothers in the Parker research group at CU Boulder, presents two meaningful conclusions. First, stress granules and other ribonucleoprotein (RNP) complexes readily form ...

The RNP complex is extremely flexible, so scientists have historically had difficulty pinning down its full structure and mechanism. But this week, structural biologists report success in taking ...

CRISPR-Cas3, a Type I CRISPR system, relies on a multi-subunit ribonucleoprotein (RNP) complex called the CRISPR-associated complex for anti-viral defense (Cascade) ...

A possible genetic rationale for why women acquire more autoimmune diseases than men has been discovered, according to findings published recently in Cell. In their study, Howard Y. Chang MD, PhD ...