Shop Lexus RX 350 vehicles for sale at Cars.com. Research, compare, and save listings, or contact sellers directly from 5,829 RX 350 models nationwide.

The Lexus RX 350 has been offered with a hybrid version named 350h since 2023. Unsurprisingly, that model majors on fuel efficiency, returning 36 mpg of combined fuel economy, according to the EPA ...

Even though the second-generation Lexus RX 350 is a reliable and well-built vehicle, we recommend that you only buy one that has a comprehensive service history. It's also a good idea to get a pre ...

Shop Lexus RX 350 SUVs for sale at Cars.com. Research, compare, and save listings, or contact sellers directly from 5,856 RX 350 models nationwide. Opens in new window. Skip to main content.

As for the 350 bit, it refers to the Lexus RX 350's V6 engine displacement, which was 3.5 liters. At the time it was introduced in 2006, the RX 350 had a 270-hp 3.5-liter 2GR-FE V6 engine that ...