A high-resolution crystal structure of the ligand-binding domain of the human nicotinic acetylcholine receptor α subunit, with three point mutations to improve its crystallization, provides both ...

We determined the crystal structure of the extracellular domain of the mouse nicotinic acetylcholine receptor (nAChR) α1 subunit bound to α-bungarotoxin at 1.94 Å resolution. This structure is ...

Muscle nicotinic receptors must respond to acetylcholine with staggering speed, opening within microseconds of their exposure to the neurotransmitter.

Muscle nicotinic receptors must respond to acetylcholine with staggering speed, opening within microseconds of their exposure to the neurotransmitter.

Muscle nicotinic receptors must respond to acetylcholine with staggering speed, opening within microseconds of their exposure to the neurotransmitter, he said.

Complete neutralization of neurotoxins was observed in patch-clamp experiments in a rhabdomyosarcoma cell line expressing the nicotinic acetylcholine receptor.

The nicotinic ACh receptors are a family of ligand-gated ion channels. This is often thought of as a precursor which cys-loop receptors descended.

Bionomics has collaborated with MSD to identify novel α7 nAChR PAMs suitable for the treatment of cognitive disorders like Alzheimer’s DiseaseBased on the learnings from Bionomics’ candidate ...

Autoantibodies specific for nicotinic acetylcholine receptors in the autonomic ganglia are potentially pathogenic and may serve as serologic markers of various forms of autoimmune autonomic ...

To determine the correlation between SARS-CoV-2 and nicotinic acetylcholine receptors (nAChRs), the researchers studied a panel of co-crystal structures along with the neurotoxin binding motif ...

When nicotine enters the brain, it binds to nicotinic acetylcholine receptors (nAChRs) on the surface of neurons. Usually bound to by the neurotransmitter acetylcholine, activation of these excitatory ...

In their study, the researchers also looked at previous findings from the 1980s and 1990s, which show how molecules of this virus bind to nicotinic acetylcholine receptors — or proteins that ...