EurekAlert!1d
FXR cyclic peptide antagonists as a novel strategy for MASH treatment
In this study, the authors first used an AlphaScreen assay to identify a series of tryptophan-based cyclic peptide compounds with FXR-antagonistic activity, specifically those modified with a ...
Medical Xpress25d
Treating liver fibrosis and metabolic dysfunction-associated steatohepatitis: Research identifies novel mechanism
This study was published online in the Journal of Hepatology. By establishing a diet-induced MASH model, researchers found that hepatocyte-specific knockout of βKlotho significantly blocked the ...
Nwd1 gene deletion triggers MASH-like pathology in mice
Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that progresses without symptoms and is associated ...
Business Wire1mon
Devonian Reports Positive Results in MASH Liver Study
The study investigated the effects of Thykamine™ on liver disease progression in the widely used STAM mouse model of MASH/fibrosis at SMC Laboratories in Japan. In this model, diabetic mice were ...
Medscape17d
Bariatric Surgery Lowers Risk for Long-Term Liver Complications in MASH-Related Cirrhosis
with MASH-related cirrhosis, Child-Pugh class A, and model for end-stage liver disease scores ≤10. Among those, 62 underwent metabolic surgery (37 Roux-en-Y gastric bypass and 25 sleeve ...
Financial Post1mon
Devonian Reports Positive Results in MASH Liver Study
We apologize, but this video has failed to load. The study investigated the effects of Thykamine™ on liver disease progression in the widely used STAM mouse model of MASH/fibrosis at SMC Laboratories ...