Nwd1 gene deletion triggers MASH-like pathology in mice
Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that progresses without symptoms and is associated ...
Medical Xpress25d
Treating liver fibrosis and metabolic dysfunction-associated steatohepatitis: Research identifies novel mechanism
This study was published online in the Journal of Hepatology. By establishing a diet-induced MASH model, researchers found that hepatocyte-specific knockout of βKlotho significantly blocked the ...
Business Wire29d
Devonian Reports Positive Results in MASH Liver Study
The study investigated the effects of Thykamine™ on liver disease progression in the widely used STAM mouse model of MASH/fibrosis at SMC Laboratories in Japan. In this model, diabetic mice were ...
Medscape17d
Bariatric Surgery Lowers Risk for Long-Term Liver Complications in MASH-Related Cirrhosis
with MASH-related cirrhosis, Child-Pugh class A, and model for end-stage liver disease scores ≤10. Among those, 62 underwent metabolic surgery (37 Roux-en-Y gastric bypass and 25 sleeve ...
Nasdaq1mon
Akero Therapeutics Reports Promising Week 96 Results for Efruxifermin in Phase 2b SYMMETRY Study of Compensated Cirrhosis Due to MASH
39% of patients in the 50mg EFX group demonstrated ≥1 stage improvement in fibrosis with no worsening of MASH, a significant finding with a p-value of 0.009 compared to placebo. Data suggests ...