The primary end point was the proportion of patients achieving goal mean trough SiDBP (<90 mm Hg) after 4 weeks of therapy with either losartan 50 mg/HCTZ 12.5 mg or a losartan monotherapy regimen ...

The 10-year predicted risk of first stroke was calculated according to the Framingham Stroke Risk Score at baseline and after a mean of 94 ± 24 days of losartan (± hydrochlorothiazide [HCTZ ...