The Food and Drug Administration announced a Class II recall for more than 7,000 bottles ... pressure-lowering drugs such as valsartan and losartan have been removed from the market since 2018 ...

In this 6-week, double-blind trial, 585 patients were randomized to losartan/ hydrochlorothiazide or losartan as monotherapy and titrated as needed at 2-week intervals to reach goal blood pressure ...

After 6 weeks, significantly more patients reached goal BP after one titration step of combination therapy vs. two titration steps of monotherapy (31% vs. 12.6%; p <0.001; Figure 2). The changes ...