In the research presented, the team developed a recombinant antiparallel helical nucleocapsid-like structure to explore the interactions within the influenza A virus’s ribonucleoprotein (RNP).

he is now hoping to capture the full progression of how the virus structure moves and changes during RNA synthesis. “If we know the structure and interactions in the helical nucleocapsid ...

More information: Florian Chenavier et al, Influenza a virus antiparallel helical nucleocapsid-like pseudo-atomic structure, Nucleic Acids Research (2024). DOI: 10.1093/nar/gkae1211 Provided by CNRS ...

1057453). By binding to a highly conserved helical region of the HIV coat protein gp41, 5-Helix prevents the virus from fusing with the membrane of its host cell. The protein works in nanomolar ...

Reference: Chenavier F, Zarkadas E, Freslon LL, et al. Influenza a virus antiparallel helical nucleocapsid-like pseudo-atomic structure. Nucleic Acids Res. 2024:gkae1211. doi: 10.1093/nar/gkae1211 ...