They found that the N-terminal end of the cytoplasmic tail of gp41, measuring 45 amino acid residues, lacked a regular secondary structure and was not associated with the membrane, which wraps around ...

This week, a new paper described how researchers pieced together the entire molecular structure of the protein shell of the HIV virus using GPU-based simulations. This remarkable achievement not ...

Want to catch a criminal? Show a mugshot on the news. Want to stop HIV infections? Get the immune system to recognize and attack the virus’s tell-tale structure. That’s part of the basic approach ...

The new Science Express study reveals the structure of the CCR5 cell surface receptor, which most strains of HIV use to enter human immune cells. This image shows CCR5 side-by-side with alternate ...

While finding HIV therapies is a main driver for Yeager's work, he points out that it also provides fundamental insights into biology. "Determining the assembly of a relatively simple structure ...

Scientists have provided the first-ever glimpse of the structure of a key protein -- gp120 -- found on the surface of a specific subgroup of the human immunodeficiency virus, HIV-1. In addition ...

The intasome is a crucial structure of the virus that enables infection, composed of the HIV protein integrase and strands of viral DNA that form when the virus enters human cells. The intasome ...

Here, we present the cryo-EM structure, at subnanometer resolution (∼6 Å at 0.143 FSC), of the 'closed', prefusion state of trimeric HIV-1 Env complexed to the broadly neutralizing antibody VRC03.

Researchers have for the first time unravelled the complex structure of the inner protein shell of HIV. The US team, reporting in Nature, also worked out exactly how all the components of the ...