Detroit swept Green Bay last season, but the early betting lines have the Lions as a slight underdog for Week 1. Using the lines from Draftkings, the Lions are a 1.5-point underdog at Lambeau, a place they won 24-14 in Week 9 in 2024.

The season-opening matchup against Dan Campbell and the Lions kicks off a 2025 schedule that might feature the first bout with one of the best players in franchise history, a daunting home slate, six stand-alone games, a Week 5 bye, a playoff rematch and, probably much to LaFleur’s delight, no international games.

As part of their 2025 NFL schedule, the Green Bay Packers have what is expected to be a tough matchup against the Detroit Lions on Sept. 7. You can see the Packers' complete schedule below. Looking for additional info on the Green Bay Packers' 2025 results and NFL schedule? We've got you covered in the piece below.