This article provides an overview of salt and water regulation, describes the pathophysiology of hyponatremia, and discusses potential indications for AVP-receptor antagonists.

Hyponatremia commonly occurs in patients with aneurysmal subarachnoid hemorrhage. Two mechanisms have been proposed as causes: syndrome of inappropriate anti-diuretic hormone and cerebral salt ...

Oral administration of the vasopressin V2-receptor antagonist tolvaptan is safe and effective for the treatment of chronic hyponatremia ... blind phase III studies (SALT-1 and SALT-2) had ...