In research, induced pluripotent stem (iPS) cells are derived from skin, urine, or blood samples and developed into other ...

The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...

L-type Ca²⁺ currents determine the shape of cardiac action potentials (AP) and the magnitude of the myoplasmic Ca²⁺ signal, which regulates the contraction force. The auxiliary Ca²⁺ channel subunits ...

The activity of SERCA2a, a crucial membrane protein located inside cardiac muscle cells (myocytes), is compromised in heart failure. SERCA2a acts as a calcium-ion pump, being responsible for the ...

Adhesion between cardiac myocytes is essential for the heart to function as an electromechanical syncytium. Although cell-matrix and cell-cell adhesions reorganize during development and disease, the ...