Scientists discovered that a well-known DNA repair pathway, the Fanconi anemia pathway, surprisingly plays a key role in repairing double-strand DNA breaks created by CRISPR-Cas9. It acts as a ...

UC Berkeley scientists discovered that a well-known DNA repair pathway, the Fanconi anemia pathway, surprisingly plays a key role in repairing double-strand DNA breaks created by CRISPR-Cas9. It ...

Scientists have developed a new CRISPR-based technology that could offer a safer approach to correcting genetic defects. The new 'soft' CRISPR approach makes use of natural DNA repair machinery ...

Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a double-strand break involves the severing of both strands of the DNA double ...

For decades, scientists have studied how to control DNA—the molecule that holds the instructions for all life. One of the most powerful tools to emerge from that effort was CRISPR, a system adapted ...

In CRISPR-Cas9 gene editing, the balance between two DNA repair pathways gets all the attention. Everybody wants to know, when Cas9 makes a cut, will DNA be repaired by non-homologous end joining ...

One reason CRISPR can fail is that when the Cas enzyme breaks DNA to insert genes of interest, the cell’s DNA repair mechanism fixes the break before the successful insertion is complete.

CRISPR-Cas9 has the reputation for being “snip happy,” for cutting and cutting a genomic site until one of the cell’s DNA repair systems finally skips a beat, leaving the site imperfectly ...

The introduction of CRISPR in space and the first successful genome manipulation on the ISS extends the possibilities for future DNA repair experiments, researchers said.

CRISPR and similar gene editing tools rely on interactions with endogenous DNA repair mechanisms, like DNA double-strand breaks (DSBs). Limitations in the understanding of DSB repair are due in part ...

Gene-editing tool CRISPR-Cas9 has garnered significant amounts of positive press in recent months, as the promise of gene editing could help with medicine and alter DNA for the better. But a new ...

Despite high hopes and high investment in CRISPR-Cas9 gene editing, scientists still have a lot to learn about how it works in humans. In the latest example, University of California, Berkeley, ...