The hairpin design with separate DNA extension signals for DNA unwinding and single-stranded DNA translocation (rezipping) allows for the detection of primosome pausing, dissociation of primase ...

Artificial DNA kills cancer Hairpin-shaped DNA binds with microRNA in cancer cells to trigger an immune response Date: December 21, 2022 Source: University of Tokyo Summary: Researchers have used ...

Thus, the stem length of an individual DNA hairpin can be determined at single-base pair resolution using a machine learning algorithm. Detection of single-nucleotide differences.

The CRISPR gene-editing system is incredibly accurate, but when there are billions of base pairs of DNA to scroll through, it's not unusual for it to be a little bit off target sometimes. Now ...

The researchers claim that these chemically-synthesized, hairpin-shaped DNA molecules could cure cancer.

These hairpin DNAs were used to investigate double-strand cleavage by bleomycin. Each of the 10 DNA samples underwent double-strand cleavage at more than one site.

“When we activate this system (with an initiator DNA molecule), a DNA hairpin structure immobilized on the origami substrate triggers a sequence of conformational changes (also known as path paving) ...

The Schlierf group used a cutting-edge microscopy setup to study how strongly a recombinase protein binds the different DNA hairpin sequences.

The team created artificial oncolytic (cancer-killing) hairpin DNA pairs called oHPs. These oHPs were triggered to form longer DNA strands when they encountered a short (micro) RNA called miR-21 ...

The team created a pair of chemically synthesized, hairpin-shaped, cancer-killing DNA. When the DNA pairs were injected into cancer cells, they connected to microRNA (miRNA) molecules that are ...