For almost 60 years, scientists have tried to understand why DNA doesn't replicate wildly and uncontrollably every time a ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

For almost 60 years, scientists have tried to understand why DNA doesn't replicate wildly and uncontrollably every time a cell divides – which they need to do constantly. Without this process, we ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

DNA, though tightly packed in the nucleus, is constantly threatened by damage from metabolism and external stressors. One particularly severe form of DNA damage is the so-called DNA–protein crosslinks ...

Unrepaired DNA-protein crosslinks (DPCs) – highly toxic tangles of protein and DNA – cause a process that leads to premature ...

CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...

Researchers have shown that harmful bonds between protein and DNA fuel immune attack in progeria. Pumping up a protein that cuts these bonds could prevent symptoms.

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by researchers at Goethe ...