Cancer-associated fibroblasts (CAFs) are crucial in melanoma metastasis, influencing tumor microenvironments and patient outcomes, especially in immunotherapy contexts. Single-cell RNA sequencing ...

In a collaboration between several labs at UNC Lineberger, researchers have defined cancer-associated fibroblast (CAF) subtypes that are clinically robust, prognostic, and predictive of immunotherapy ...

UT Southwestern Medical Center researchers have identified two distinct populations of cells known as antigen-presenting cancer-associated fibroblasts (apCAFs) that appear to support the survival and ...

Cancer-associated fibroblasts (CAFs) – critical but enigmatic players in tumors – exhibit "paradoxical" effects on immunotherapy, according to a new review in Clinical and Translational Discovery.

Tumours have developed many strategies and tricks to gain advantages in the body. Led by cell biology professor Sabine Werner, researchers at ETH Zurich have now discovered another surprising trick ...

A small clinical trial led by Dana-Farber Cancer Institute researchers has put a Salk Institute idea to the test in patients: that activating the vitamin D receptor can help reshape the protective ...