Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, providing insights into its DNA recognition and cleavage mechanisms.

The most used CRISPR-Cas system in gene editing is the CRISPR-Cas9 system, which is a type II system belonging to Class 2. The first Cas9, SpCas9, was obtained from Streptococcus pyogenes.

They consist of two main components; the CRISPR array, which stores immune memory of past viral infections, and the cas genes (encoding Cas proteins), responsible for coordinating the different stages ...

New CRISPR-Cas system with on-off switch cuts proteins. Delft University of Technology. Journal Science DOI 10.1126/science.add5064 ...

Moving toward clinical development, the researchers demonstrated efficient delivery of mRNA mitochondrial base editors using ...

That’s not nearly as good as CRISPR-Cas, which has the benefit of the years scientists have spent optimizing the system. One potential advantage Fanzor has over CRISPR-Cas is its diminutive size.

Rather than being famous in gene editing field only, by revealing the collateral cleavage activity of Cas12a, Cas13a, Cas14 effectors, and more, Clustered Regularly Interspaced Short Palindromic ...

In this case, the microbes’ immune system, dubbed CRISPR-Cas, or more casually, just CRISPR, shreds any viral genome that matches the sequences in their molecular memory banks. The yogurt-makers weren ...