The core components of CRISPR-based genome-editing therapies are bacterial proteins called nucleases that can stimulate ...

signaling the system to initiate gene silencing. "The 'R' in R-loop stands for RNA. All DNA-binding CRISPR-Cas systems use this structure to probe the DNA sequence and identify the correct target ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

Yet others, called base editors, change one letter of the DNA code to another. So why do we call it CRISPR? Cas proteins are used by bacteria to destroy viral DNA. They add bits of viral DNA to ...

Treatments for rare diseases are hard to create and expensive to deliver, but there is new hope for editing the software of ...

especially in understanding the functions of Cas proteins and developing novel CRISPR-based tools for biotechnology applications. (Image: Doudna Lab, UC Berkeley) In the CRISPR-Cas9 system, the guide ...

Genome editing with CRISPR-Cas is often associated with the induction of mutations. However, a team of researchers from the ...

Researchers at the Experimental and Clinical Research Center (ECRC), a joint institution of the Max Delbrück Center and ...

Researchers have been working to find CRISPR/Cas nucleases with greater specificity ... team used a GFP activation expression reporting system to screen 13 Cas12b nucleases. Interestingly, one ...

Gene therapies based on the CRISPR-Cas system have already been successfully used in clinical practice. In recent years, for example, a hundred patients suffering from the hereditary disease ...